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Genatlas database, genes and development defects

J Frézal1

  • 1Service de génétique médicale, hôpital des Enfants-malades, Paris, France. frezalj@necker.fr

Comptes Rendus De L'Academie Des Sciences. Serie III, Sciences De La Vie
|December 3, 1998
PubMed
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The Genatlas database highlights human developmental genes and their links to diseases. Understanding these genes is crucial for congenital malformation research.

Area of Science:

  • Developmental Biology
  • Human Genetics
  • Medical Informatics

Background:

  • Developmental genes are critical from early embryonic stages, regulating cascades from signaling to gene activation.
  • Many human developmental genes are orthologs of genes found in simpler organisms.
  • These genes are increasingly mapped and linked to congenital anomalies, revealing complex genetic and phenotypic patterns.

Purpose of the Study:

  • To demonstrate the capabilities of the Genatlas database.
  • To showcase the role of developmental genes in human diseases.
  • To provide insights into the genetic basis of congenital malformations.

Main Methods:

  • Utilizing the Genatlas database for gene identification and mapping.
  • Analyzing developmental genes and their association with human diseases.

Related Experiment Videos

  • Reviewing literature on gene orthologs and congenital anomalies.

    • Main Results:

    • Identification of numerous developmental genes involved in human embryogenesis.
    • Association of specific developmental genes with a wide spectrum of congenital malformations.
    • Demonstration of significant genetic and phenotypic heterogeneity in developmental disorders.

    Conclusions:

    • The Genatlas database is a valuable resource for studying developmental genes and diseases.
    • Understanding developmental gene function is key to elucidating congenital malformation mechanisms.
    • Further research is needed to unravel the complexity of genetic and phenotypic variations in these disorders.