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Related Experiment Videos

Development of amphotericin B loaded nanoparticles

N Sen1, A Samanta, S Baidya

  • 1Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.

Bollettino Chimico Farmaceutico
|December 3, 1998
PubMed
Summary

Researchers developed Amphotericin B nanoparticles using ethylcyanoacrylate via in-situ emulsion polymerization. Higher monomer concentrations increased drug adsorption, with 72.1% loading achieved at optimal levels.

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Area of Science:

  • Nanotechnology
  • Polymer Chemistry
  • Pharmaceutical Sciences

Background:

  • Amphotericin B is a critical antifungal agent with limitations in solubility and toxicity.
  • Nanoparticle drug delivery systems offer potential to improve Amphotericin B's therapeutic index.
  • Ethylcyanoacrylate is explored as a monomer for nanoparticle synthesis.

Purpose of the Study:

  • To synthesize and characterize Amphotericin B loaded nanoparticles.
  • To investigate the effect of ethylcyanoacrylate concentration on drug loading.
  • To evaluate the suitability of nanoparticles for drug delivery.

Main Methods:

  • In-situ emulsion polymerization technique was employed for nanoparticle preparation.
  • Scanning Electron Microscopy (SEM) was used to analyze nanoparticle morphology.

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  • Particle size analysis determined the colloidal range of the nanoparticles.
  • Drug adsorption was quantified at varying monomer concentrations.

    • Main Results:

    • Spherical and discrete nanoparticles were successfully prepared.
    • Average particle size ranged from 475.3 to 479.75 nm, falling within the colloidal range.
    • Drug adsorption percentage increased with higher ethylcyanoacrylate concentrations.
    • Optimal ethylcyanoacrylate concentration (21.6 microliters/ml) resulted in 72.1% Amphotericin B adsorption.

    Conclusions:

    • Ethylcyanoacrylate is a suitable monomer for creating Amphotericin B loaded nanoparticles.
    • Nanoparticle characteristics, including size and drug loading, are influenced by monomer concentration.
    • The developed nanoparticles show promise for improved Amphotericin B delivery.