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Related Experiment Videos

Pseudotumour cerebri after varicella

D Konrad1, H Kuster, U A Hunziker

  • 1Kinderklinik, Kantonsspital Winterthur, Switzerland. dkonrad@kispi.unizh.ch

European Journal of Pediatrics
|December 3, 1998
PubMed
Summary

Varicella (chickenpox) can cause blood clots in children, potentially due to anti-protein S antibodies. Prompt treatment is crucial for managing these thrombotic events.

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Area of Science:

  • Pediatric Thrombosis
  • Infectious Disease Complications
  • Autoimmunity

Background:

  • Varicella (chickenpox) is a common childhood viral infection.
  • Thrombotic complications, though known, are less frequently discussed in pediatric varicella cases.
  • Protein S deficiency has been implicated in some thrombotic events.

Observation:

  • An 8-year-old girl developed pseudotumor cerebri with abducens palsy and ileofemoral vein thrombosis three weeks post-varicella.
  • Laboratory tests revealed transient anti-protein S auto-antibodies.
  • Initial treatment with heparin resolved the pseudotumor cerebri but not the deep vein thrombosis.

Findings:

  • The case suggests a link between varicella infection and the development of anti-protein S antibodies.
  • These antibodies may lead to transient protein S deficiency, contributing to thrombotic events.
  • The specific presentation included both intracranial hypertension and deep vein thrombosis.

Implications:

  • Thrombotic complications following varicella may be mediated by auto-antibodies against protein S.
  • Early identification of anti-protein S antibodies is critical for effective treatment.
  • Recombinant tissue-type plasminogen activator may be a beneficial therapeutic option for severe cases.

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