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Papillomavirus vaccines

M F Duggan-Keen1, M D Brown, S N Stacey

  • 1Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester M20 4BX, United Kingdom.

Frontiers in Bioscience : a Journal and Virtual Library
|December 4, 1998
PubMed
Summary
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Human papillomavirus (HPV) vaccines are being developed to combat significant disease and death. Ongoing clinical trials will determine the efficacy of prophylactic and therapeutic HPV vaccines.

Area of Science:

  • Oncology
  • Virology
  • Immunology

Background:

  • Certain human papillomaviruses (HPV) cause significant morbidity and mortality.
  • The need for effective interventions has driven HPV vaccine development.

Purpose of the Study:

  • To review the development of HPV vaccines.
  • To discuss the evaluation of prophylactic and therapeutic vaccine strategies.

Main Methods:

  • Review of HPV infection nature and consequences.
  • Evaluation of vaccination approaches in animal models.
  • Analysis of ongoing Phase I and II clinical trials.

Main Results:

  • Several HPV vaccine candidates have been produced.
  • Vaccine preparations are currently in early-stage clinical trials.

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Conclusions:

  • Widespread use of prophylactic HPV vaccines requires large-scale efficacy studies considering HPV epidemiology.
  • Therapeutic HPV vaccines must demonstrate significant improvement over existing treatments.