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[Cholinesterases]

C Lejus1, Y Blanloeil, P Burnat

  • 1Service d'anesthésie-réanimation chirurgicale, CHR, Nantes, France.

Annales Francaises D'Anesthesie Et De Reanimation
|December 4, 1998
PubMed
Summary
This summary is machine-generated.

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Butyrylcholinesterase (BChE) activity assessment alone cannot diagnose genetic variants. Deficits over 50% significantly alter drug metabolism, requiring neuromuscular monitoring for prolonged blockade. Diagnosis of BChE variants is confirmed by biochemical or genetic methods.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Genetics

Background:

  • Butyrylcholinesterase (BChE) plays a role in drug hydrolysis, distinct from acetylcholinesterase.
  • Its precise physiological function remains largely unknown.
  • Various pathological conditions and genetic mutations can affect BChE activity.

Purpose of the Study:

  • To review current data on butyrylcholinesterase (BChE).
  • To explore its biochemical structure, action, and pathological variations.
  • To highlight recent findings from molecular biology regarding genetic variants.

Main Methods:

  • Literature search of Medline databases for articles in English and French.
  • Selection of original articles and case reports, excluding letters to the editor.

Related Experiment Videos

  • Analysis of data on BChE structure, function, variations, and genetic identification.

    • Main Results:

    • BChE differs from acetylcholinesterase; it hydrolyzes succinylcholine.
    • Physiological role of BChE is unknown, but it metabolizes many drugs.
    • Significant BChE deficits (>50%) impact succinylcholine and mivacurium metabolism.
    • Diagnosis of prolonged neuromuscular blockade requires monitoring.
    • Biochemical tests (dibucaine, fluoride) and familial studies aid diagnosis of common variants.
    • Molecular genetic methods (PCR, restriction enzymes) provide rapid diagnosis when results are uncertain.

    Conclusions:

    • BChE activity levels do not diagnose genetic variants.
    • Monitoring neuromuscular function is crucial for patients receiving succinylcholine or mivacurium.
    • Biochemical and genetic analyses are essential for diagnosing BChE deficiencies and variants.