Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Platelet alloantigenic systems]

L Hallé1

  • 1Institut national de la transfusion sanguine, Paris, France.

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|December 4, 1998
PubMed
Summary

Human Platelet Antigen (HPA) systems, crucial for platelet identification, follow a specific nomenclature based on allele frequency. Advances in molecular biology may necessitate future adjustments to this system.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Human platelet antigen allele frequencies in different Algerian populations.

Tissue antigens·2010
Same author

New mutations on platelet GPIIb in Sub-Saharan African populations revealed by genotyping discrepancies.

Transfusion·2008
Same author

HPA polymorphism in sub-Saharan African populations: Beninese, Cameroonians, Congolese, and Pygmies.

Tissue antigens·2005
Same author

Eleven human platelet systems studied in the Vietnamese and Ma'ohis Polynesian populations.

Tissue antigens·2003
Same author

HLA class II polymorphism in Aka Pygmies and Bantu Congolese and a reassessment of HLA-DRB1 African diversity.

Tissue antigens·2002
Same author

Gene frequencies of human platelet antigens in the Tunisian population.

Tissue antigens·1999

Area of Science:

  • Immunology
  • Hematology
  • Genetics

Context:

  • Platelet-specific alloantigen systems involve glycoproteins on the platelet membrane.
  • These systems are characterized as di-allelic, resulting from single amino acid substitutions.

Purpose:

  • To outline the established nomenclature for Human Platelet Antigens (HPA).
  • To describe the rules governing HPA system designation and allele naming (e.g., HPA-1a, HPA-1b).

Summary:

  • The International Society on Thrombosis and Haemostasis (ISTH) established the HPA nomenclature in 1990.
  • HPA systems are numbered chronologically, with the most frequent allele designated 'a' and the less frequent 'b'.
  • Molecular biology advancements highlight potential imprecision in the current HPA nomenclature, suggesting a future need for revision.

Impact:

  • Provides a foundational understanding of platelet antigen classification.
  • Highlights the dynamic nature of scientific nomenclature in response to technological progress.
  • Informs future research and clinical practices related to platelet alloimmunization and transfusion compatibility.

Related Experiment Videos