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Related Experiment Videos

Mucous elements in the airways

M Tos

    Acta Oto-Laryngologica
    |September 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    This study details mucous and goblet cell density in the respiratory tract from fetus to adult. Goblet cell density increases in the trachea with disease or dust exposure.

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    Area of Science:

    • Anatomy
    • Histology
    • Respiratory System

    Background:

    • The human respiratory tract's mucosal lining is crucial for defense and function.
    • Variations in mucous and goblet cell distribution across different age groups and anatomical locations are not fully elucidated.

    Purpose of the Study:

    • To quantify and compare mucous gland and goblet cell density in the nasal cavity, rhinopharynx, pharynx, hypopharynx, and trachea.
    • To investigate age-related changes and the impact of environmental factors on these cell types.

    Main Methods:

    • Whole-mount histological techniques were employed.
    • Analysis included specimens from fetuses, infants, children, and adults.

    Main Results:

    • Glandular density was highest in the nose and lowest in the trachea, though tracheal glands were larger.

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  • Nasal, pharyngeal, and hypopharyngeal glands had more serous components than tracheal glands.
  • Goblet cell density peaked in the rhinopharynx and was lowest in the anterior nose.
  • Tracheal goblet cell density increased with acute/chronic disease and dust exposure.

    • Conclusions:

    • Significant regional and age-related variations exist in respiratory tract mucosal glands and goblet cells.
    • Goblet cell density in the trachea is sensitive to pathological conditions and environmental irritants like dust.