Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

84.0K
Overview
84.0K
Humoral Immune Responses01:36

Humoral Immune Responses

83.8K
Overview
83.8K
What is the Immune System?01:38

What is the Immune System?

127.7K
Overview
127.7K
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

8.8K
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
8.8K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

1.9K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.9K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

9.2K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
9.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An integrated safety analysis of treatment-emergent fungal infections in patients with psoriasis treated with ixekizumab from 16 clinical studies.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

'Hidradenitis suppurativa and amyloidosis: a possible association with the pyrin inflammasome': reply from authors.

Clinical and experimental dermatology·2021
Same author

Hidradenitis suppurativa and sleep disorders: a population-based study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

The underestimated risk for complications in immunocompetent patients with herpes zoster: should we change our clinical practice?

The British journal of dermatology·2021
Same author

Relationship of amyloid beta and neurofibrillary tau deposition in Neurodegeneration in Aging Down Syndrome (NiAD) study at baseline.

Alzheimer's & dementia (New York, N. Y.)·2020
Same author

Big data highlights the association between psoriasis and fibromyalgia: a population-based study.

Immunologic research·2020
Same journal

Rational Inhibitor Discovery for BRAF<sup>V600E</sup> Using PSeMut, a Sequence-Driven Model.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

METTL3-Activated IDO1-Kynurenine Pathway in Insulin-Producing Cells Enhances Graft Survival and Attenuates Endogenous Islet Apoptosis in Diabetic Mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Time- and Region-Specific Effects of Intranasal Insulin on Oxidative Stress Parameters in the Rat Brain.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Brown Adipose Tissue Secreted Nrg4 Prevents Bone Loss by Orchestrates Bone Resorption and Angiogenesis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

Shared Genetic Risk Between Acute Pancreatitis and Metabolic Syndrome Converges on a BCAT1-Positive Fibroblast Subpopulation and MAPK14-Driven Inflammation.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
Same journal

IL-33/ST2 Signaling Sustains Hepato-Intestinal Homeostasis by Orchestrating Vascular Surveillance and Immune Regulatory Circuits During Experimental Trypanosoma cruzi Infection.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026
See all related articles

Related Experiment Video

Updated: Jan 29, 2026

Assessing Respiratory Immune Responses to Haemophilus Influenzae
06:32

Assessing Respiratory Immune Responses to Haemophilus Influenzae

Published on: June 29, 2021

2.5K

Modulating the immune response to genetic immunization

A D Cohen1, J D Boyer, D B Weiner

  • 1Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|December 5, 1998
PubMed
Summary
This summary is machine-generated.

Genetic immunization, a novel vaccine strategy, uses plasmid DNA to induce immune responses against in vivo produced antigens. This adaptable approach allows for tailored vaccines and immunotherapies for various diseases.

More Related Videos

Quantitative Measurement of the Immune Response and Sleep in Drosophila
12:16

Quantitative Measurement of the Immune Response and Sleep in Drosophila

Published on: December 4, 2012

16.0K
An Introduction to Parasitic Wasps of Drosophila and the Antiparasite Immune Response
13:04

An Introduction to Parasitic Wasps of Drosophila and the Antiparasite Immune Response

Published on: May 7, 2012

19.2K

Related Experiment Videos

Last Updated: Jan 29, 2026

Assessing Respiratory Immune Responses to Haemophilus Influenzae
06:32

Assessing Respiratory Immune Responses to Haemophilus Influenzae

Published on: June 29, 2021

2.5K
Quantitative Measurement of the Immune Response and Sleep in Drosophila
12:16

Quantitative Measurement of the Immune Response and Sleep in Drosophila

Published on: December 4, 2012

16.0K
An Introduction to Parasitic Wasps of Drosophila and the Antiparasite Immune Response
13:04

An Introduction to Parasitic Wasps of Drosophila and the Antiparasite Immune Response

Published on: May 7, 2012

19.2K

Area of Science:

  • Biotechnology
  • Immunology
  • Vaccinology

Background:

  • Genetic immunization, also known as DNA or polynucleotide immunization, is an innovative vaccine development strategy.
  • It involves direct administration of plasmid DNA encoding antigens to a host, leading to in vivo antigen expression and a targeted immune response.
  • This method has demonstrated efficacy in experimental models for infectious diseases and cancer.

Purpose of the Study:

  • To explore the potential of genetic immunization as a novel vaccine development strategy.
  • To investigate the mechanisms and modifiability of immune responses induced by DNA vaccination.
  • To highlight the potential for designing tailored vaccines and immunotherapeutic agents.

Main Methods:

  • Direct administration of plasmid DNA encoding antigens to the host.
  • Induction of host expression of the delivered foreign gene.
  • Modulation of immune response magnitude and orientation by altering immunization conditions (e.g., method, location, plasmid features, regimen, coadministration of cytokine/costimulatory genes).

Main Results:

  • DNA immunization induces specific immune responses against in vivo produced antigens.
  • Protective immune responses have been observed in experimental models for infectious diseases and cancer.
  • DNA vaccines are progressing into clinical trials for prophylactic and therapeutic applications.

Conclusions:

  • The immune response generated by DNA vaccination is highly malleable and can be manipulated.
  • By optimizing administration conditions, vaccines and immunotherapeutic agents can be tailored to specific disease correlates of protection.
  • This adaptability promises a new generation of more focused and effective immune-stimulating agents.