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Synthesis and antiplatelet activity of phenyl quinolones
L J Huang1, M C Hsieh, C M Teng
1Graduate Institute of Pharmaceutical Chemistry, China Medical College, Taichung, Taiwan.
Bioorganic & Medicinal Chemistry
|December 5, 1998
Abstract:
In our search for novel antiplatelet agents, seven positional phenyl quinolone isomers were synthesized. Preliminary screening confirmed their inhibitory effects against arachidonic acid (AA)-induced platelet aggregation. Varying the substitutional position of the phenyl group had a profound effect on the antiplatelet activity of these isomers. 3-Phenyl-4-quinolone showed the greatest potency and was superior to indomethacin, although the two structures are quite different. The mechanism and pharmacological action of 3-phenyl-4-quinolone are currently under investigation.