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Sensitivity and specificity of several immunochemical tests for colorectal cancer
1Department of Public Health, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
Background/Aim:
The purpose of this study was to evaluate the diagnostic accuracy of new different immunochemical fecal occult blood tests for colorectal cancer, including Iatro Hemcheck, Immudia-Hem Sp, LA Hemochaser, Monohaem and OC-Hemodia.
Methodology:
Ninety-six patients with colorectal cancer and the same number of healthy controls served as subjects for the study. In this study, each subject received a set of five immunochemical tests over three consecutive days; and sensitivities and specificity of these tests were evaluated.
Results:
Mean sensitivity and specificity in a set of five immunochemical tests were 91.0% and 95.2%, respectively. Sensitivities and specificity of five different immunochemical tests were calculated as 92.7% and 92.7% for Iatro-Hemcheck, 90.6% and 96.9% for Immudia-Hem Sp, 88.5% and 96.9% for LA Hemochaser, 91.7% and 95.8% for Monohaem, and 91.7% and 93.8% for OC-Hemodia, respectively, showing no significant difference in sensitivity and specificity among five tests.
Conclusions:
These results suggest that immunochemical tests for fecal occult blood tests has high diagnostic validity for colorectal cancer. In addition, there is no significant difference in the degree of accuracy among the several types of immunochemical tests.