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Depression with anger attacks

M Fava1

  • 1Depression Clinical and Research Program, Massachusetts General Hospital, Boston 02114, USA.

The Journal of Clinical Psychiatry
|December 5, 1998
PubMed
Summary
This summary is machine-generated.

A subtype of depression includes irritability and anger attacks. Antidepressant treatment effectively reduces these anger attacks and improves depressive symptoms, showing promise for this specific patient group.

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Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Neuroscience

Background:

  • Unipolar depressive disorders exhibit significant heterogeneity.
  • A distinct subtype characterized by irritability and anger attacks has been identified.

Purpose of the Study:

  • To investigate the characteristics and treatment response of depressed outpatients with anger attacks.
  • To compare outcomes for patients with and without anger attacks.

Main Methods:

  • Phenomenologic studies and clinical observation.
  • Analysis of patient data on anger attacks, associated symptoms, personality disorders, and response to antidepressant treatment.

Main Results:

  • Approximately one-third of depressed outpatients experience anger attacks.

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  • Patients with anger attacks show higher rates of certain personality disorders and comparable improvement with antidepressants.
  • Antidepressant treatment leads to subsidence of anger attacks in 53-71% of patients, with a lower emergence rate than placebo.

    • Conclusions:

    • Anger attacks represent a specific subtype of depression with a distinct clinical profile.
    • Antidepressant therapy is effective for both depressive symptoms and anger attacks in this subtype.
    • Further research into serotonergic antidepressants for this subtype is warranted.