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Reversible parkinsonism induced by prolonged treatment with valproate

M Onofrj¹, A Thomas, C Paci

¹Dipartimento di Oncologia e Neuroscienze, Clinica Neurologica, Chieti, Italy. onofrj@ibmpe.unich.it

Journal of Neurology

|December 5, 1998

Abstract:

We describe two patients who developed levodopa-responsive parkinsonism without dementia at least 4 years after beginning chronic valproate (VPA) treatment for seizures. Parkinsonism disappeared in less than 3 months after VPA substitution with carbamazepine.

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