Related Experiment Videos
Angiosarcomas associated with bone infarcts
I F Abdelwahab1, M J Klein, G Hermann
1Department of Radiology, Mount Sinai Medical Center, New York, NY 10029-6574, USA.
Skeletal Radiology
|December 5, 1998
Summary
This study presents three rare cases of angiosarcoma associated with bone infarcts. The findings suggest a potentially poor prognosis, similar to other sarcomas linked to bone infarcts, and hint at a possible causal link.
Area of Science:
- Orthopedic Oncology
- Vascular Pathology
- Skeletal Radiology
Background:
- Bone infarcts are rarely associated with sarcomas, typically osteogenic sarcoma, fibrosarcoma, or malignant fibrous histiocytoma.
- The association between bone infarcts and angiosarcoma is exceptionally rare.
Observation:
- Three male patients, mean age 43, presented with high-grade angiosarcoma arising from a bone infarct in the femur.
- Radiography, CT, and MRI were used for diagnosis, with pathological fracture noted in two cases.
- Open biopsy confirmed angiosarcoma in all three cases.
Findings:
- Treatment varied: amputation, segmental resection with adjuvant therapy, and intramedullary rodding.
- Survival outcomes were mixed, with one patient alive at 3 years post-treatment and another deceased at 6 months.
- The overall survival rate appears unfavorable, comparable to other sarcomas linked to bone infarcts.
Implications:
- This series adds to the limited cases of angiosarcoma associated with bone infarcts, establishing its rarity.
- The findings suggest a potential cause-and-effect relationship between bone infarcts and the development of bone sarcomas.
- Further research is needed to understand the pathogenesis and improve prognostic outcomes for this rare condition.