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Related Experiment Videos

Endothelin-1 and bronchial hyperresponsiveness in the rabbit

B D'Agostino1, A Filippelli, M Falciani

  • 1Institute of Pharmacology and Toxicology, Naples, Italy. brdagost@unina.it

Naunyn-Schmiedeberg'S Archives of Pharmacology
|December 5, 1998
PubMed
Summary

Endothelin-1 (ET-1) can increase airway responsiveness to histamine in rabbits, independent of inflammatory cell changes. Capsaicin-sensitive nerves are likely involved in maintaining this ET-1-induced bronchial hyperresponsiveness.

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Area of Science:

  • Respiratory Medicine
  • Pharmacology
  • Immunology

Background:

  • Endothelins (ETs) are peptide mediators with potent bronchoconstrictor properties.
  • Elevated endothelin-1 (ET-1) levels are found in asthma patients' bronchoalveolar lavage fluid.
  • The role of ET-1 in bronchial hyperresponsiveness and inflammation requires further investigation.

Purpose of the Study:

  • To investigate the contribution of ET-1 to bronchial hyperresponsiveness.
  • To determine the role of inflammatory cell accumulation in ET-1-induced airway changes.
  • To explore the involvement of capsaicin-sensitive nerves in ET-1's effects.

Main Methods:

  • Rabbits were challenged with ET-1 or vehicle.
  • Airway responsiveness to inhaled histamine was measured.

Related Experiment Videos

  • Bronchoalveolar lavage (BAL) assessed inflammatory cell counts.
  • Capsaicin pre-treatment was used to assess nerve involvement.

    • Main Results:

    • ET-1 challenge significantly increased airway responsiveness to histamine (3-fold increase, P<0.01).
    • No significant changes in total or differential inflammatory cell counts were observed post-ET-1.
    • Capsaicin pre-treatment inhibited the ET-1-induced increase in airway responsiveness 24 hours later.

    Conclusions:

    • ET-1 plays a role in developing bronchial hyperresponsiveness to histamine.
    • The maintenance of this hyperresponsiveness is not due to cellular infiltration but likely involves capsaicin-sensitive nerves.