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Determination of celiprolol and oxprenolol in human plasma by high-performance liquid chromatography and the
A J Braza1, P Modamio, E L Mariño
1Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Barcelona, Spain.
Journal of Chromatography. B, Biomedical Sciences and Applications
|December 5, 1998
Abstract:
Two reversed-phase HPLC methods with UV detection to quantify celiprolol and oxprenolol in human plasma are described. The analytical methods for the determination of both drugs used the same reversed-phase HPLC column, mobile phase and extraction procedure. Linearity was obtained in the ranges 15.63-1000 and 25-800 ng/ml for celiprolol and oxprenolol, respectively. Intra-day and inter-day variation was lower than 14%. After validation of the methods, analytical error functions were established as S.D. (ng/ml)=3.096+0.041C for celiprolol and S.D. (ng/ml)=8.906+8.075x10(-8)C3 for oxprenolol.