Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Atrial pacing in patients with sinus node dysfunction

M M Scheinman, F W Kunkel, R W Peters

    The American Journal of Medicine
    |November 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Patient-derived epithelial cell organoids mimic the phenotypic complexity of endometriosis subtypes.

    Human reproduction (Oxford, England)·2025
    Same author

    Twenty-four hour ambulatory electrocardiography in healthy dogs: reference intervals and measurement variability.

    The Journal of small animal practice·2025
    Same author

    Evaluation of right ventricular function using conventional and real-time three-dimensional echocardiography in healthy dogs and dogs with myxomatous mitral valve disease.

    Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2024
    Same author

    'Vaginal Laser Therapy for GSM/VVA: Where We Stand Now - A Review by the EUGA Working Group on Laser'.

    Climacteric : the journal of the International Menopause Society·2023
    Same author

    The longitudinal outcome of canine (K9) myxomatous mitral valve disease (LOOK-Mitral) registry: Baseline treatment characteristics.

    Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2022
    Same author

    Idioventricular tachycardia and unstable ventricular escape rhythm in a canine patient with third-degree atrioventricular block.

    Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology·2021
    Same journal

    GLP-1 Receptor Agonists and Age-related Macular Degeneration Risk in Diabetes or Non-diabetic Obesity: A Retrospective Cohort Study.

    The American journal of medicine·2026
    Same journal

    Marijuana Use and Acute Myocardial Infarction: Mechanistic Insights, Clinical Implications, and Emerging Challenges.

    The American journal of medicine·2026
    Same journal

    Cave Canem - Beware of the Dog.

    The American journal of medicine·2026
    Same journal

    Risk Factors for 30-day Hospital Readmission After Hospital-at-Home Treatment of Acute Pyelonephritis.

    The American journal of medicine·2026
    Same journal

    Mesenteric Panniculitis.

    The American journal of medicine·2026
    Same journal

    Hypercalcemia and hyperferritinemia in a patient with Graves' disease disease.

    The American journal of medicine·2026
    See all related articles

    Sinus node recovery time (SNRT) tests showed significant overlap between patients and controls, failing to reliably diagnose sinus node disease. Heart rate correction did not improve test accuracy for this condition.

    Area of Science:

    • Electrophysiology
    • Cardiology
    • Clinical Research

    Background:

    • Symptomatic sinus node disease diagnosis relies on electrophysiological testing.
    • Sinus node recovery time (SNRT) is a commonly used parameter.
    • Limited data exists on the diagnostic accuracy of SNRT and atrial effective refractory periods (AERP) in sinus node disease.

    Purpose of the Study:

    • To evaluate the diagnostic utility of SNRT and AERP in patients with symptomatic sinus node disease.
    • To compare electrophysiological parameters between patients and healthy controls.

    Main Methods:

    • Studied 33 patients with symptomatic sinus node disease and 42 normal subjects.
    • Measured SNRT at paced rates of 100 and 120 bpm (SNRT100, SNRT120).
    • Assessed AERP at spontaneous and paced rates (AERP, AERP100, AERP120) and used premature atrial stimulation.

    Related Experiment Videos

    Main Results:

    • Mean SNRT100 and SNRT120 were significantly greater in patients than controls, but with substantial overlap.
    • SNRT100/SNRT120 showed a 30.3% false-negative and 5% false-positive rate.
    • Heart rate correction of SNRT did not enhance sensitivity or specificity.
    • No significant differences in AERP or sinoatrial conduction time were found between groups.
    • Premature atrial stimulation revealed abnormal curves in only 5 of 24 patients.

    Conclusions:

    • SNRT is not a sufficiently sensitive or specific test for diagnosing sinus node disease due to significant overlap between patients and controls.
    • AERP and sinoatrial conduction time do not differentiate patients from controls.
    • Further investigation into perinodal fiber refractoriness may be needed for specific cases identified by premature atrial stimulation.