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Perfusion imaging using FOCI RF pulses

M N Yongbi1, C A Branch, J A Helpern

  • 1Center for Advanced Brain Imaging, The Nathan S. Kline Institute, Orangeburg, New York, USA.

Magnetic Resonance in Medicine
|December 5, 1998
PubMed
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Frequency offset corrected inversion (FOCI) pulses offer sharper slice profiles for arterial spin tagging perfusion imaging. While not increasing perfusion signal, FOCI pulses minimize static signal errors in rat brain studies.

Area of Science:

  • Magnetic Resonance Imaging
  • Neuroimaging
  • Physiology

Background:

  • Pulsed arterial spin-tagging (ASL) techniques are crucial for non-invasive perfusion measurements.
  • Conventional hyperbolic secant (HS) pulses are widely used for spin inversion in ASL, but their performance is limited by inversion efficiency and slice profile sharpness.
  • Frequency offset corrected inversion (FOCI) pulses offer improved slice profile characteristics compared to conventional HS pulses.

Purpose of the Study:

  • To implement and evaluate the C-shape FOCI pulse for perfusion imaging using the FAIR technique in rat brains.
  • To assess the impact of FOCI pulses on FAIR perfusion signal magnitude and static signal subtraction errors.
  • To demonstrate the suitability of FOCI pulses for in vivo perfusion studies.

Main Methods:

Related Experiment Videos

  • Implementation of a C-shape FOCI pulse for spin inversion in the FAIR perfusion technique.
  • Theoretical and experimental evaluation of FOCI pulse performance compared to conventional HS pulses.
  • In vivo perfusion imaging of rat brains using FAIR with FOCI and conventional HS pulses.

Main Results:

  • FOCI pulses provide sharper slice profiles than conventional HS pulses.
  • The use of FOCI tagging pulses did not increase the FAIR perfusion signal.
  • FOCI inversion pulses significantly reduced static signal subtraction errors.

Conclusions:

  • FOCI pulses, despite sharper profiles, do not enhance FAIR perfusion signal magnitude.
  • FOCI pulses effectively minimize static signal subtraction errors in ASL perfusion imaging.
  • The C-shape FOCI pulse is suitable for in vivo perfusion studies, particularly for reducing artifacts.