Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

IgM myeloma: case report with immunophenotypic profile

B Haghighi1, R Yanagihara, P J Cornbleet

  • 1Stanford University Medical Center, Department of Pathology, California 94305, USA. jcornbleet@pathology.standord.edu

American Journal of Hematology
|December 5, 1998
PubMed
Summary

Immunoglobulin (Ig)M myeloma, a subtype of multiple myeloma (MM), exhibits a unique hybrid phenotype. This finding aids in distinguishing IgM myeloma from classic multiple myeloma and Waldenström

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Swelling of Doubly Magic ^{48}Ca Core in Ca Isotopes beyond N=28.

Physical review letters·2020
Same author

High prevalence of human T-lymphotropic virus type I infection in isolated populations of the Western Pacific region confirmed by Western immunoblot.

American journal of human biology : the official journal of the Human Biology Council·2017
Same author

Human T-lymphotropic virus type I: A retrovirus causing chronic myeloneuropathies in tropical and temperate climates.

American journal of human biology : the official journal of the Human Biology Council·2017
Same author

Fabrication of a liquid-gated enzyme field effect device for sensitive glucose detection.

Analytica chimica acta·2016
Same author

Nano-sized manganese-calcium cluster in photosystem II.

Biochemistry. Biokhimiia·2014
Same author

Epidermal growth factor receptor and p53 protein expression in human glioblastomas.

European journal of neurology·2013

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Multiple myeloma (MM) and Waldenström's macroglobulinemia (WM) are distinct B-cell malignancies.
  • Immunoglobulin (Ig)M myeloma presents features of both MM and WM.
  • The immunophenotypic profile of IgM myeloma has not been previously characterized.

Observation:

  • A case of IgM myeloma was analyzed using flow cytometry.
  • Cells displayed a hybrid phenotype, expressing plasma cell markers (CD38) and B-cell markers (CD20, FMC7, weak surface Ig).
  • Discordant B-cell antigen expression was noted, with absence of CD19 and CD22.

Findings:

  • IgM myeloma cells showed a unique surface antigen expression profile.
  • The phenotype included strong CD38 expression (plasma cell feature) and positive CD20, FMC7, and weak surface Ig (B-cell malignancy features).

Related Experiment Videos

  • Absence of CD45, DR, CD19, CD22, CD23, CD10, and CD5 further defined the hybrid phenotype.

    • Implications:

    • This study characterizes the distinct immunophenotype of IgM myeloma.
    • The findings suggest IgM myeloma represents a unique entity with characteristics of both MM and WM.
    • Understanding this unique phenotype may improve diagnostic accuracy and guide therapeutic strategies.