Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Exercise training enhances basic fibroblast growth factor-induced collateral blood flow

H T Yang1, R W Ogilvie, R L Terjung

  • 1Department of Physiology, Health Science Center at Syracuse, State University of New York, Syracuse, New York 13210, USA.

The American Journal of Physiology
|June 25, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence for the Collective Nature of Radial Flow in Pb+Pb Collisions with the ATLAS Detector.

Physical review letters·2026
Same author

Evidence for the Dimuon Decay of the Higgs Boson in pp Collisions with the ATLAS Detector.

Physical review letters·2025
Same author

Evidence for Longitudinally Polarized W Bosons in the Electroweak Production of Same-Sign W Boson Pairs in Association with Two Jets in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Observation of tt[over ¯] Production in Pb+Pb Collisions at sqrt[s_{NN}]=5.02  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Fully-gapped superconductivity with rotational symmetry breaking in pressurized kagome metal CsV<sub>3</sub>Sb<sub>5</sub>.

Nature communications·2025
Same author

Search for Dark Matter Produced in Association with a Dark Higgs Boson in the bb[over ¯] Final State Using pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025
Same journal

Blood coagulation in fish.

The American journal of physiology·2011
Same journal

Renal tubular reabsorption, metabolic utilization and isomeric fractionation of lactic acid in the dog.

The American journal of physiology·2010
Same journal

The inactivation of placental toxin by human serum.

The American journal of physiology·2010
Same journal

Adrenal function following ovariectomy in the rat.

The American journal of physiology·2010
Same journal

Capillary permeability; perfusion of frog and guinea pig hind limbs.

The American journal of physiology·2010
Same journal

Evaluation of protective measures against sunburn.

The American journal of physiology·2010
See all related articles

Daily exercise combined with basic fibroblast growth factor (bFGF) significantly boosts collateral blood flow and muscle function in rats. This synergy enhances the development of new blood vessels, improving circulation in the hindlimb.

Area of Science:

  • Physiology
  • Vascular Biology
  • Exercise Science

Background:

  • Peripheral artery disease impairs blood flow, leading to muscle ischemia.
  • Basic fibroblast growth factor (bFGF) promotes collateral vessel development.
  • The role of exercise in augmenting bFGF-mediated angiogenesis is not fully understood.

Purpose of the Study:

  • To investigate if daily exercise enhances collateral circulation induced by exogenous basic fibroblast growth factor (bFGF) infusion.
  • To assess the combined effects of bFGF and exercise on hindlimb blood flow and muscle performance.

Main Methods:

  • Male Sprague-Dawley rats underwent bilateral femoral artery occlusion.
  • Animals received intra-arterial bFGF or carrier solution infusions for 2 weeks.

Related Experiment Videos

  • Subgroups were either sedentary or trained via treadmill exercise (2x daily, 5 days/wk for 4 wk).
  • Muscle citrate synthase activity, hindlimb blood flow (85Sr microspheres), and muscle function were measured.

    • Main Results:

    • Exercise training significantly increased muscle citrate synthase activity.
    • bFGF infusion increased hindlimb blood flow in sedentary rats.
    • Combined bFGF treatment and exercise training resulted in the greatest increase in collateral blood flow (approx. 240% in calf muscles).
    • Improved blood flow correlated with enhanced calf muscle performance.

    Conclusions:

    • Exogenous bFGF administration combined with moderate-intensity exercise significantly enhances collateral-dependent blood flow.
    • Physical activity potentiates the angiogenic response to bFGF.
    • Hemodynamic factors stimulated by exercise are crucial for collateral vessel enlargement.