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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

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Published on: September 9, 2012

Thrombophilia and activated protein C resistance

C H Selzman1, T A Whitehill, W C Krupski

  • 1Section of Vascular Surgery, University of Colorado Health Sciences Center, Denver, CO, USA.

Annals of Vascular Surgery
|December 5, 1998
PubMed

In addition to classic vascular insults such as inflammation, trauma, malignancy, and surgery, a number of hereditary coagulation defects predispose patients to a wide array of thrombotic complications. A novel genetic defect in factor V allowing for resistance to its cleavage by activated protein C has recently been implicated in a significant number of cases of familial thrombophilia. A brief case report and review of the literature is presented to familiarize surgeons to this important and quite frequent cause of hypercoagulability.

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