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Case report of a 22-week fetus with 47,XXX karyotype and multiple lower mesodermal defects
M P Hoang1, K S Wilson, N R Schneider
1Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA.
Abstract:
A 22-week stillborn fetus with 47,XXX karyotype had lower mesodermal defects consisting of irregular fusion of the sacral vertebrae, anal agenesis, multicystic dysplasia of a horseshoe kidney, a single umbilical artery, dysplastic ovaries, and uterine hypoplasia. This case provides additional evidence for an association between trisomy X and genitourinary defects including lower mesodermal defects sequence.