Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human papillomavirus vaccine development

K H Fife1

  • 1Indiana University School of Medicine, Indianapolis 46202-5124, USA.

The Australasian Journal of Dermatology
|December 8, 1998
PubMed
Summary

Developing a human papillomavirus (HPV) vaccine faces challenges in understanding immune response and requires new diagnostic tools. Future vaccines may need different antigens for prophylactic or therapeutic use against HPV infections and related cancers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acyclovir and transmission of HIV-1 from persons infected with HIV-1 and HSV-2.

The New England journal of medicine·2010
Same author

Down-regulation of MHC class I is a property common to papillomavirus E5 proteins.

Virus research·2006
Same author

The psychosocial impact of serological diagnosis of asymptomatic herpes simplex virus type 2 infection.

Sexually transmitted infections·2006
Same author

Increased frequency of dosing of imiquimod 5% cream in the treatment of external genital warts in women.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics·2002
Same author

Neutralization of human papillomavirus type 11 (HPV-11) by serum from women vaccinated with yeast-derived HPV-11 L1 virus-like particles: correlation with competitive radioimmunoassay titer.

The Journal of infectious diseases·2001
Same author

Detection of multiple human papillomavirus types in the lower genital tract correlates with cervical dysplasia.

Journal of medical virology·2001

Area of Science:

  • Virology
  • Immunology
  • Vaccinology

Background:

  • Vaccines represent significant advancements in managing viral infections.
  • Human papillomavirus (HPV) infections are linked to genital tract malignancies, including cervical cancer.
  • An effective HPV vaccine could decrease cancer-related morbidity and mortality.

Purpose of the Study:

  • To identify barriers in human papillomavirus (HPV) vaccine development.
  • To explore the potential of L1 major capsid protein in vaccine design.
  • To address the need for reliable serological assays and therapeutic vaccine strategies.

Main Methods:

  • Review of current understanding of HPV immunology and vaccine development challenges.
  • Evaluation of L1 major capsid protein (virus-like particles) immunogenicity in animal models.
  • Discussion of serological assay limitations and therapeutic vaccine antigen considerations.

Main Results:

  • Immunization with L1 protein elicits neutralizing antibodies in animal models.
  • Uncertainty remains regarding the quantity of neutralizing antibodies in the genital tract to prevent infection.
  • A significant barrier is the lack of a reliable serological assay for HPV diagnosis in clinical trials.

Conclusions:

  • Overcoming immunological and diagnostic challenges is crucial for HPV vaccine development.
  • Further research is needed to ensure adequate genital tract antibody levels for protection.
  • Therapeutic HPV vaccines may require distinct antigens compared to prophylactic vaccines.

Related Experiment Videos