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Body composition and long-term levo-carnitine supplementation

G M Trovato1, E Iannetti, A M Murgo

  • 1Istituto di Medicina Interna e Terapia Medica, University of Catania, Italy. unictmedintgmt@ctonline.it

La Clinica Terapeutica
|December 8, 1998
PubMed
Summary

Long-term levocarnitine supplementation improved the nutritional status of patients undergoing maintenance dialysis. This intervention led to higher protein and albumin levels without adverse effects on body composition or dialysis adequacy.

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Area of Science:

  • Nephrology
  • Nutritional Science
  • Biochemistry

Background:

  • Patients undergoing maintenance dialysis often experience malnutrition.
  • Maintaining adequate protein levels is crucial for dialysis patients.

Purpose of the Study:

  • To assess the impact of long-term levocarnitine supplementation on the nutritional status of patients on maintenance dialysis.
  • To investigate potential changes in body composition and dialysis adequacy.

Main Methods:

  • A comparative study involving two groups of patients on maintenance bicarbonate hemodialysis.
  • Patients were assessed using multifrequency bioelectric impedance analysis (BIA).
  • One group received levocarnitine (1g/day) for at least three years; the control group did not.

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Main Results:

  • Levocarnitine supplementation was linked to elevated serum total protein and albumin levels compared to controls.
  • No detrimental increases in body fat mass or total body water were observed.
  • These improvements occurred without negative impacts on circulatory or blood pressure parameters.

Conclusions:

  • Levocarnitine supplementation effectively enhances the nutritional state in dialysis patients.
  • The improvement is associated with increased protein intake and catabolism.
  • Levocarnitine supplementation does not compromise dialysis efficacy or adequacy.