Related Experiment Videos
[High-dose chemotherapy of metastatic breast carcinoma]
A Tartarone1, M Aieta, M G Morritti
1Divisione di Oncologia, Casa Sollievo della Sofferenza, IRCCS, S. Giovanni Rotondo, Italia.
Purpose:
To evaluate efficacy and toxicity of high-dose chemotherapy (HDCT) in metastatic breast cancer (MBC) MATERIALS AND METHODS: A literature search from January 1988 until July 1998 about the treatment of metastatic breast cancer with high dose chemotherapy was conducted.
Results:
After HDCT the overall response rate was about 80%, with 50% of complete remissions. The median survival was > 18 months. Approximately 20% of the patients experienced long-term progression-free survival.
Conclusions:
Although current results appear promising, randomised trials are required to determine the role of HDCT in the treatment of patients with MBC.