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[Thyroid function and difficult to manage asthma]

F R Jerez1, V Plaza, J Tárrega

  • 1Departament de Pneumologia, Hospital de la Santa Creu i Sant Pau, Bercelona.

Archivos De Bronconeumologia
|December 8, 1998
PubMed
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Systematic thyroid function tests are not recommended for all difficult-to-manage asthma patients. While hyperthyroidism can worsen asthma, routine screening is not cost-effective for these patients.

Area of Science:

  • Endocrinology
  • Pulmonology
  • Internal Medicine

Context:

  • Hyperthyroidism is known to exacerbate asthma, leading to recommendations for thyroid function analysis in cases of unfavorable asthma progression.
  • Difficult-to-manage asthma presents a clinical challenge, prompting investigation into potential underlying contributing factors.

Purpose:

  • To evaluate the utility of systematic thyroid function analysis in all patients experiencing difficult-to-manage asthma.
  • To determine if routine screening for thyroid dysfunction is beneficial in this specific patient population.

Summary:

  • A prospective study involved 48 asthma patients with unexplained deterioration. Thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels were assessed, along with clinical evaluation for thyroid disease.
  • Thyroid dysfunction was suspected in 19% of patients, with abnormal TSH in 10%. Hyperthyroidism was confirmed in 6% of the total cohort.

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  • The study concluded that systematic thyroid function investigation is not broadly justified for all difficult-to-manage asthma cases due to a low yield of confirmed thyroid disease.

    • Impact:

    • Findings suggest that targeted thyroid screening, based on clinical suspicion, may be more appropriate than universal screening in difficult-to-manage asthma.
    • This research informs clinical guidelines regarding the investigation of comorbidities in complex respiratory conditions.
    • Highlights the importance of considering endocrine-respiratory interactions in patient management.