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Related Experiment Videos

[Somatostatin: a ubiquitous peptide]

J Epelbaum1, P Dournaud

  • 1U159 INSERM, Centre Paul Broca, Paris.

Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|December 8, 1998
PubMed
Summary

Somatostatin (SRIF) is a neurohormone discovered in 1973 that inhibits Growth Hormone (GH) secretion. This review covers SRIF systems, peptides, receptors, and their roles in health and disease.

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Area of Science:

  • Neuroendocrinology
  • Molecular Biology
  • Pharmacology

Context:

  • Somatostatin (SRIF) discovered in 1973 as a Growth Hormone (GH) inhibiting neurohormone.
  • SRIF functions centrally and peripherally as a hormone, autocrine/paracrine factor, and neuropeptide.
  • SRIF receptors are present on human tumors, with agonists used clinically for acromegaly.

Purpose:

  • To review the properties of central and peripheral somatostatinergic systems.
  • To discuss the three peptides in the somatostatin family: SRIF14, SRIF28, and cortistatin.
  • To cover SRIF receptor pharmacology, ontogeny, phylogeny, and pathology.

Summary:

  • The review details the diverse roles and distribution of somatostatin (SRIF) in mammals.
  • It explores the somatostatin family peptides (SRIF14, SRIF28, cortistatin) and their five receptor subtypes.
  • Pathological aspects and evolutionary context of the somatostatinergic system are also addressed.

Impact:

  • Provides a comprehensive overview of the somatostatinergic system for researchers and clinicians.
  • Highlights the therapeutic potential of somatostatin analogs in endocrine disorders and oncology.
  • Establishes a foundation for further research into somatostatin's complex physiological and pathological functions.

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