Related Experiment Video
Updated: Oct 26, 2026

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
Published on: September 6, 2019
Retention behavior of positional isomers of disubstituted cyclomalto-oligosaccharide (cyclodextrin) derivatives on an
T Tanimoto1, A Ikuta, K Koizumi
1School of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Japan.
Abstract:
The correlation between hydrophobic effects and structures of three and four positional isomers of 6(1),6n-di-O-triphenylmethyl (trityl)- or 6(1),6n-di-O-tert.- butyldimethylsilyl (tert.-BuMe2Si)-cyclomaltohexaoses (cG6s, alpha-cyclodextrin) (n = 2-4), -cyclomaltoheptaoses (cG7s, beta-cyclodextrin) (n = 2-4), and -cyclomaltooctaoses (cG8s, gamma-cyclodextrin) (n = 2-5) on an ODS column are discussed. Cyclodextrins with two hydrophobic-substituted groups bonded to hydroxyl groups tended to show low retention of positional isomers in which the binding positions of the two substituted groups on the cyclodextrin ring were far apart from each other.
More Related Videos
13:06Improved In-gel Reductive β-Elimination for Comprehensive O-linked and Sulfo-glycomics by Mass Spectrometry
Published on: November 20, 2014
11:44Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B
Published on: January 19, 2022
Related Concept Videos
Disubstituted Cyclohexanes: cis-trans Isomerism
In cyclohexane, the substituents can occupy different positions generating distinct isomers.
Stereoisomerism of Cyclic Compounds
Stability of Substituted Cyclohexanes
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
Silica Gel Column Chromatography: Overview
Polar components tend to bind strongly to the silica gel, causing them to move slowly through the column. In contrast, nonpolar compounds...
Analyte Adsorption and Distribution
Diels–Alder Reaction Forming Bridged Bicyclic Products: Stereochemistry