Related Experiment Videos
Sweet's syndrome: is the pathogenesis mediated by helper T cell type 1 cytokines?
A S Giasuddin1, A H El-Orfi, M M Ziu
1Department of Laboratory Medicine, Faculty of Medicine, Al-Arab Medical University, Benghazi, Libya.
Background:
The pathogenesis of Sweet's syndrome (acute febrile neutrophilic dermatosis; SS) is still not fully understood. An imbalance between helper T cell types 1 and 2 cytokine secretion patterns has been shown to be relevant in many diseases.
Objective:
We assessed the serum cytokine levels (interleukin [IL]-1alpha, IL-1beta, IL-2, interferon gamma [IFN-gamma], IL-4) in patients with SS.
Methods:
Eight patients with SS were analyzed for their clinical features and serum cytokine levels and compared with normal control subjects.
Results:
In patients serum levels of IL-1alpha, IL-1beta, IL-2, and IFN-gamma were significantly elevated, whereas the IL-4 level was within the normal range.
Conclusion:
Our findings suggest that the pathogenesis of SS is probably mediated through helper T cell type 1 cytokines (IL-2, IFN-gamma) rather than helper T cell type 2 cytokines (IL-4).