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Effects of dantrolene sodium on fibrillation potentials in denervated rat muscles
S I Izumi1, A Tsubahara, N Chino
1Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, Japan.
Muscle & Nerve
|December 8, 1998
Abstract:
To examine whether a decrease in cytosolic Ca2+ affects fibrillation potentials, we studied effects of dantolene on these potentials in denervated rat muscle. Administered intraperitoneally, dantrolene sodium (12-22 mg/kg) abolished fibrillation potentials and subthreshold oscillating potentials over 2.5-6 h without affecting excitability of the muscle to electrical stimulation. Fibrillation potentials reappeared 36-96 h after administration of dantrolene. We suggest that cytosolic Ca2+ has a specific role in generating fibrillations.