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Bronchial vascular contribution to lung lymph flow

E M Wagner1, S Blosser, W Mitzner

  • 1Departments of Medicine and Environmental Health Sciences, The Johns Hopkins University, Baltimore, Maryland 21224, USA. wagnerem@welchlink.welch.jhu.edu

Journal of Applied Physiology (Bethesda, Md. : 1985)
|December 8, 1998
PubMed
Summary

Lung lymphatic vessels help clear airway fluid. This study shows bronchial circulation significantly impacts lung lymph flow, especially during inflammation or fluid overload, highlighting lymphatics

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Area of Science:

  • Pulmonary Physiology
  • Lymphatic System Biology

Background:

  • Lung lymphatic vessels primarily clear interstitial fluid from pulmonary blood vessels.
  • The role of lung lymphatics in removing airway liquid from bronchial circulation is not well understood.

Purpose of the Study:

  • To investigate the contribution of bronchial vascular circulation to lung lymph flow.
  • To determine if bronchial circulation influences lymphatic clearance of airway fluid.

Main Methods:

  • Anesthetized, ventilated sheep (n=35) were used.
  • Bronchial artery perfusion was manipulated (control, increased flow, bradykinin infusion).
  • Lymph flow was measured from the caudal mediastinal lymph node efferent duct under various conditions, including left atrial hypertension.

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Main Results:

  • Increased bronchial perfusion significantly elevated lung lymph flow (35%).
  • Bronchial perfusion amplified lymph flow increase during left atrial hypertension (339% vs 138%) and impaired recovery.
  • Bradykinin infusion into the bronchial artery, but not the pulmonary artery, increased lymph flow (107%).

Conclusions:

  • Bronchial vascular transudate significantly contributes to lung lymph flow.
  • Lung lymphatics are crucial for clearing excess fluid from the airway wall.
  • Bronchial vascular permeability and fluid dynamics are important considerations in airway obstruction.