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Related Experiment Videos

Perinatal mortality after epidural analgesia

H David, M Rosen

    Anaesthesia
    |October 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Epidural blocks for labor pain relief showed no significant difference in overall perinatal mortality. However, they were associated with fewer early deaths in low-birth-weight infants.

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    Area of Science:

    • Obstetrics and Gynecology
    • Anesthesiology
    • Perinatal Medicine

    Background:

    • Retrospective survey of 6442 births in Cardiff (1973-1974).
    • Lumbar epidural block used in 13.7% of births primarily for pain relief.
    • Emphasis on avoiding aorto-caval compression during epidural administration.

    Observation:

    • Perinatal mortality rates: 14.8/1000 for epidural block vs. 19.2/1000 for other analgesia (not significantly different).
    • Lower first-week mortality in infants <2.5 kg with epidural block (0/45) compared to other methods (41/414, P=0.023).
    • No significant influence of maternal medication on immature infant mortality, but a trend favoring epidural block in premature infants.

    Findings:

    • Epidural block did not significantly alter overall perinatal mortality.

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  • A significant reduction in early deaths was observed in low-birth-weight infants (<2.5 kg) receiving epidural analgesia.
  • Potential confounding factor: increased forceps delivery associated with epidural use.

    • Implications:

    • Further controlled trials of epidural block in premature fetal management are indicated.
    • Epidural analgesia may offer benefits for low-birth-weight infants, warranting further investigation.
    • No observed increase or reduction in perinatal mortality for babies >2.5 kg or mature infants with epidural use.