Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamics of extracellular fluid volume changes during hyperproteinemia

R D Manning1

  • 1Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216-4505, USA.

The American Journal of Physiology
|December 9, 1998
PubMed
Summary

Hyperproteinemia in dogs leads to increased blood volume and arterial pressure with overhydration. However, these effects plateau, similar to normal protein levels, indicating a limit to fluid expansion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fab five: pioneering sociocultural influence within the culture of basketball and American society.

Frontiers in sports and active living·2024
Same author

Intrarenal Angiotensin ii is associated with inflammation, renal damage and dysfunction in dahl salt-sensitive hypertension.

Journal of the American Society of Hypertension : JASH·2010
Same author

Interactions between oxidative stress and inflammation in salt-sensitive hypertension.

American journal of physiology. Heart and circulatory physiology·2007
Same author

Immune suppression prevents renal damage and dysfunction and reduces arterial pressure in salt-sensitive hypertension.

American journal of physiology. Heart and circulatory physiology·2006
Same author

Renal and vascular oxidative stress and salt-sensitivity of arterial pressure.

Acta physiologica Scandinavica·2003
Same author

Role of abnormal nitric oxide systems in salt-sensitive hypertension.

American journal of hypertension·2001

Area of Science:

  • Physiology
  • Fluid dynamics
  • Renal physiology

Background:

  • Understanding fluid shifts between blood and interstitium is crucial.
  • Hyperproteinemia can alter fluid distribution.
  • Previous studies on short-term effects exist.

Purpose of the Study:

  • To investigate fluid volume distribution dynamics during chronic hyperproteinemia.
  • To assess the impact of hydration levels on blood volume and arterial pressure under hyperproteinemia.

Main Methods:

  • 12 anephric dogs underwent plasma protein elevation via autologous plasma infusion.
  • Hydration was manipulated using lactated Ringer solution (10% or 20% body weight).
  • Circulating protein mass, blood volume, arterial pressure, and sodium space were monitored.

Related Experiment Videos

Main Results:

  • Overhydration in hyperproteinemic dogs increased circulating protein mass (10% group) or decreased it (20% group).
  • Both blood volume and arterial pressure increased significantly with hydration, but effects plateaued.
  • The relationship between blood volume and sodium space mirrored normoproteinemic conditions.

Conclusions:

  • Chronic hyperproteinemia combined with overhydration induces hypervolemia and hypertension in dogs.
  • The compensatory mechanisms for fluid expansion appear limited, similar to normoproteinemic states.
  • These findings contrast with short-term studies, suggesting adaptive responses over time.