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Related Experiment Videos

Early physiological abnormalities after simian immunodeficiency virus infection

T F Horn1, S Huitron-Resendiz, M R Weed

  • 1Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Proceedings of the National Academy of Sciences of the United States of America
|December 9, 1998
PubMed
Summary

Early simian immunodeficiency virus (SIV) infection in monkeys causes physiological changes, including disrupted circadian rhythms and reduced motor activity. These abnormalities may signal future central nervous system (CNS) dysfunction.

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Area of Science:

  • Neuroscience
  • Immunology
  • Virology

Background:

  • Central nervous system (CNS) damage is a severe outcome of HIV infection.
  • Early viral-induced abnormalities affecting CNS function remain poorly understood.

Purpose of the Study:

  • To detect and characterize early physiological abnormalities in simian immunodeficiency virus (SIV)-infected monkeys.
  • To identify potential biomarkers for early CNS dysfunction.

Main Methods:

  • Monitoring physiological parameters (body temperature, motor activity) in SIV-infected monkeys postinoculation.
  • Analyzing sensory-evoked responses, specifically auditory-evoked potentials.

Main Results:

  • Acute SIV infection disrupted circadian rhythms, causing hyperthermia and reduced motor activity (50% of control levels) within 1-2 weeks.

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  • Hyperthermia persisted for 2 months, while motor activity initially recovered then declined again.
  • Auditory-evoked potential latencies showed distinct, persistent changes at 1 and 3 months postinoculation.

    • Conclusions:

    • Early physiological abnormalities, including circadian disruption and altered sensory responses, occur during SIV infection.
    • These findings suggest potential preclinical indicators of CNS dysfunction.
    • The observed abnormalities may serve as an assay for evaluating therapeutic agents targeting neuronal dysfunction.