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Islet transplantation as a treatment for diabetes
1Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, Massachusetts, USA.
Background:
The microvascular complications of diabetes are directly linked to hyperglycemia. Beta-cell failure is a critical factor in regulation of blood sugar levels. However, only a small proportion of persons with type 1 and type 2 diabetes obtain sufficient glycemic control to avoid complications.
Methods:
There are two routes for beta-cell replacement, transplantation, and a mechanical beta cell equivalent. Beta-cell replacement therapy is a potential treatment modality, since diabetes is caused by beta-cell failure.
Results:
An obvious path for glycemic control is some form of beta-cell replacement therapy. Successful islet transplantation is a difficult challenge, but current achievements with human pancreas transplants and islet allografts may greatly improve glycemic control.
Conclusion:
Beta-cell replacement therapy is an accepted treatment modality for diabetes.