[Sildenafil]

Sildenafil is an innovative molecule, effective in most cases of erectile dysfunction, acting by inhibition of type 5 phosphodiesterase in the corpus cavernosum. Its impressive success attests its efficacy and the frequency of erectile dysfunction in man. The authors review the clinical data and call for caution in its prescription requiring a thorough check-up of the cardiovascular system taking into account its potentially letal interactions with nitrates.