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Related Experiment Videos

Hsp90 as a capacitor for morphological evolution

S L Rutherford1, S Lindquist

  • 1Howard Hughes Medical Institute, University of Chicago, Illinois 60637, USA.

Nature
|December 9, 1998
PubMed
Summary
This summary is machine-generated.

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Heat-shock protein 90 (Hsp90) normally silences genetic variation. Impairing Hsp90 reveals this cryptic variation, allowing selection to drive evolutionary change in developmental pathways.

Area of Science:

  • Developmental biology
  • Evolutionary genetics
  • Molecular chaperones

Background:

  • Heat-shock protein 90 (Hsp90) is crucial for signal transduction and developmental pathways.
  • Hsp90 acts as a buffer, masking underlying genetic variation.

Purpose of the Study:

  • To investigate the role of Hsp90 in buffering phenotypic variation.
  • To explore how Hsp90 impairment affects the expression of cryptic genetic variation.
  • To understand the evolutionary implications of Hsp90's buffering capacity.

Main Methods:

  • Utilizing Drosophila melanogaster as a model organism.
  • Employing genetic mutations and pharmacological inhibition to impair Hsp90 function.
  • Analyzing phenotypic variation in adult structures under different genetic backgrounds and environmental conditions.

Related Experiment Videos

  • Employing selection experiments to assess the stability of expressed variants.

    • Main Results:

    • Impaired Hsp90 function in Drosophila leads to widespread phenotypic variation across adult structures.
    • This variation is dependent on the genetic background and present in both lab and wild populations.
    • Previously silent genetic determinants underlie these variants.
    • Selection can stabilize these variants, making them independent of Hsp90 function.
    • Environmental factors like temperature can trigger the expression of cryptic variation.

    Conclusions:

    • Hsp90 plays a significant role in buffering cryptic genetic variation in natural populations.
    • Compromising Hsp90 function reveals this variation, facilitating evolutionary adaptation.
    • This mechanism provides a pathway for rapid evolutionary change in developmental processes.