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Radiation-induced changes in bone perfusion and angiogenesis

P Okunieff¹, X Wang, P Rubin

¹Department of Radiation Oncology, Strong Memorial Hospital, Rochester, NY 14642, USA. okunieff@radonc.medinfo.rochester.edu

International Journal of Radiation Oncology, Biology, Physics

|December 9, 1998

Summary

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Radiation therapy reduces bone growth and blood flow. Basic fibroblast growth factor (bFGF) therapy improved bone growth after irradiation but did not restore blood flow in the irradiated limb.

Area of Science:

Oncology
Vascular Biology
Regenerative Medicine

Background:

Radiation therapy can cause significant long-term complications, including impaired bone growth and altered vascular function.
Understanding the mechanisms behind radiation-induced tissue damage is crucial for developing effective therapeutic interventions.

Purpose of the Study:

To investigate the impact of limb irradiation on bone blood flow.
To evaluate the potential of basic fibroblast growth factor (bFGF) to mitigate radiation-induced bone growth and blood flow abnormalities.

Main Methods:

C3H mice underwent hind limb irradiation at varying doses (0-30 Gy).
Groups received bFGF treatment intravenously at different time points post-irradiation.
Bone growth was assessed via serial X-rays, and limb blood flow was measured using laser Doppler flowmetry (LDF) at 33 weeks.

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Main Results:

Irradiation dose-dependently reduced bone growth.
bFGF treatment improved bone growth, even when initiated weeks after radiation.
No significant improvement in LDF was observed in the irradiated limb; however, LDF increased in the contralateral limb, potentially enhanced by bFGF.

Conclusions:

Radiation induces a chronic antiangiogenic effect leading to reduced limb growth.
bFGF therapy alleviates radiation-induced bone toxicity, suggesting potent local antiangiogenic mechanisms.
Increased blood flow in the non-irradiated limb may be a compensatory response to circulating angiogenic factors.