Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antisulfatide polyneuropathy: antibody-mediated complement attack on peripheral myelin

S Ferrari1, M Morbin, E Nobile-Orazio

  • 1Department of Neurological and Visual Sciences, Policlinico Borgo Roma, Verona, Italy.

Acta Neuropathologica
|December 9, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protein Expression of Canine and Feline Muscular Dystrophies.

Topics in companion animal medicine·2020
Same author

Response to: SARS-CoV-2 associated Guillain-Barré syndrome in 62 patients.

European journal of neurology·2020
Same author

Chronic inflammatory demyelinating polyradiculoneuropathy: can a diagnosis be made in patients not fulfilling electrodiagnostic criteria?

European journal of neurology·2020
Same author

Guillain-Barré syndrome associated with SARS-CoV-2 infection. A systematic review.

European journal of neurology·2020
Same author

Chronic immune sensory polyradiculopathy (CISP): First juvenile case description.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2020
Same author

Risk factors for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): antecedent events, lifestyle and dietary habits. Data from the Italian CIDP Database.

European journal of neurology·2019
Same journal

Mutation-specific neuropathologic signatures in MAPT-associated frontotemporal lobar degeneration.

Acta neuropathologica·2026
Same journal

Molecular changes during AT/RT progression associated with epithelial-mesenchymal transition and extracellular matrix changes.

Acta neuropathologica·2026
Same journal

Prion-like transmission and propagation of human β-amyloid to the bank vole rodent model.

Acta neuropathologica·2026
Same journal

Inhibition of tRNA fragments dysregulated in human mTLE exacerbates pathology and seizure activity.

Acta neuropathologica·2026
Same journal

VMA21 deficiency leads to autophagic dysregulation and altered vesicle trafficking in X-linked myopathy with excessive autophagy.

Acta neuropathologica·2026
Same journal

Donor-specific pathological features associate with genetic background, lesion type distribution, and clinical heterogeneity in multiple sclerosis.

Acta neuropathologica·2026
See all related articles

Antisulfatide antibodies in demyelinating polyneuropathy activate the complement system, leading to myelin damage. This suggests complement-mediated pathology in neuropathy associated with these antibodies.

Area of Science:

  • Neurology
  • Immunology
  • Pathology

Background:

  • Antisulfatide antibodies are linked to chronic neuropathies.
  • Their precise role in nerve dysfunction remains unclear.

Observation:

  • Sural nerve biopsies from two patients with neuropathy and high IgM anti-sulfatide antibodies were analyzed.
  • Findings showed demyelination and characteristic myelin abnormalities.

Findings:

  • Immunocytochemistry revealed IgM and complement (C3d, C1q, C5) bound to myelin sheaths.
  • The terminal complement complex (C5b-C9) was detected on some myelinated fibers.
  • Myelin splitting at intraperiod lines was observed ultrastructurally.

Implications:

  • Pathological changes in these neuropathies appear to be complement-mediated.

Related Experiment Videos

  • Complement activation contributes to myelin damage in sulfatide antibody-associated demyelinating polyneuropathy.