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Related Experiment Videos

Delivered dialysis dose with PD Plus therapy. A multicenter study

J A Diaz-Buxo1, B P Youngblood, A M Torres

  • 1Fresenius Medical Care - North America, Peritoneal Dialysis Services, Walnut Creek, Calif., USA.pdserve@bellsouth.net

American Journal of Nephrology
|December 10, 1998
PubMed
Summary
This summary is machine-generated.

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PD Plus significantly improved dialysis adequacy, with 45% achieving target Kt/Vurea and 47% reaching adequate creatinine clearance (Kcr), compared to 20% with standard CAPD/CCPD.

Area of Science:

  • Nephrology
  • Renal Replacement Therapy
  • Dialysis Technology

Background:

  • Continuous ambulatory peritoneal dialysis (CAPD) and continuous cyclic peritoneal dialysis (CCPD) are common renal replacement therapies.
  • Optimizing dialysis dose is crucial for patient outcomes in end-stage renal disease.

Purpose of the Study:

  • To evaluate the efficacy of PD Plus in enhancing dialysis adequacy.
  • To assess the impact of PD Plus on weekly Kt/Vurea and creatinine clearance (Kcr) in CAPD/CCPD patients.

Main Methods:

  • Analysis of kinetic studies from 110 patients (92 CAPD, 18 CCPD) transitioned to PD Plus.
  • Comparison of achieved dialysis indices (Kt/Vurea, Kcr) with modeled targets.
  • Inclusion of supervised patient data to validate modeling accuracy.

Related Experiment Videos

Main Results:

  • PD Plus use resulted in 45% of patients achieving a weekly Kt/Vurea >= 2.1, and 47% achieving Kcr >= 60 L/1.73 m², significantly higher than baseline CAPD/CCPD (20%).
  • A strong correlation was observed between supervised patient results and modeled therapy predictions.
  • Higher fill volumes, supine positioning, and optimal dwell times with PD Plus facilitated adequate dialysis.

Conclusions:

  • PD Plus is an effective strategy for improving dialysis adequacy in CAPD/CCPD patients.
  • Discrepancies between modeled and achieved dialysis doses may stem from compliance, training, or specimen collection issues.
  • Optimized PD Plus protocols can help most patients achieve target dialysis doses.