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Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
Published on: June 22, 2016
[Physiological analysis of stress-induced changes in the suppressor activity of mouse T-lymphocytes]
1Institute of Experimental Medicine of the Russian Acad. Sci., St. Petersburg, Russia.
Suppressor activity of the T-lymphocytes was studied by means of evaluating the alterations in humoral immune response in the system of adoptive transfer of splenocytes from immunised donors (PFC/106 splenocytes) in mice. Administration of glucocorticoids or stress prior to the immunisation decreased the suppressor activity of the T-lymphocytes and enhanced humoral immune response. In adrenalectomised mice, absence of glucocorticoid hormones in the blood did not prevent normal development of the suppressor functions of the T-lymphocytes. Administration of Interleukin-1 prior to the stress or hydrocortisone administration normalised the T-lymphocytes' functions.
Suppressor activity of the T-lymphocytes was studied by means of evaluating the alterations in humoral immune response in the system of adoptive transfer of splenocytes from immunised donors (PFC/106 splenocytes) in mice. Administration of glucocorticoids or stress prior to the immunisation decreased the suppressor activity of the T-lymphocytes and enhanced humoral immune response. In adrenalectomised mice, absence of glucocorticoid hormones in the blood did not prevent normal development of the suppressor functions of the T-lymphocytes. Administration of Interleukin-1 prior to the stress or hydrocortisone administration normalised the T-lymphocytes' functions.
