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Related Experiment Videos

Immunotherapy and mast cell activation

A G Carlos1, M L Carlos, M A Santos

  • 1Clinica Universitaria de Medicina I, Instituto de Imunologia e Centro de Hematologia e Imunologia, Faculdade de Medicina de Lisboa, Portugal.

Allergie Et Immunologie
|December 10, 1998
PubMed
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Specific immunotherapy significantly reduced tryptase release in nasal lavage fluid after allergen challenge in patients with Parietaria allergy. This indicates decreased mast cell activation following treatment.

Area of Science:

  • Allergy and Immunology
  • Mast Cell Biology

Background:

  • Tryptase is a specific marker for mast cell activation and mediator release.
  • Mast cell activation plays a key role in allergic reactions.

Purpose of the Study:

  • To evaluate the effect of specific systemic immunotherapy on tryptase release after nasal allergen challenge.
  • To confirm tryptase as a reliable marker of mast cell activation in allergic rhinitis.

Main Methods:

  • Nasal provocation tests were performed in patients allergic to Parietaria pollen.
  • Tryptase levels were measured in nasal lavage fluid before and after immunotherapy.
  • Concentrations of tryptase were evaluated at various challenge levels.

Main Results:

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  • Specific immunotherapy significantly decreased tryptase concentration in nasal lavage fluid.
  • The peak tryptase release was delayed after immunotherapy.
  • Tryptase levels correlated with challenge concentrations, confirming its role as a marker.

    • Conclusions:

    • Assays of tryptase in nasal fluid after nasal provocation are reliable indicators of mast cell activation.
    • Specific allergen immunotherapy reduces mast cell reactivity to the allergen.