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The exfoliation syndrome

H S Sugar, C Harding, D Barsky

    Annals of Ophthalmology
    |October 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    The term pseudoexfoliation should be replaced with exfoliation syndrome. Exfoliative fibrils likely originate from the iris and ciliary body epithelium, with deposits forming on the lens capsule.

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    Area of Science:

    • Ophthalmology
    • Cell Biology
    • Microscopy

    Background:

    • Exfoliation syndrome is a condition characterized by the deposition of fibrillar material.
    • The origin and nomenclature of this material have been debated.
    • Previous studies have utilized various microscopy techniques to investigate the syndrome.

    Purpose of the Study:

    • To review the clinical and ultramicroscopic findings of exfoliation syndrome.
    • To propose a revised terminology, replacing "pseudoexfoliation" with "exfoliation syndrome."
    • To identify the primary sources of exfoliative fibrils.

    Main Methods:

    • Clinical examination of patients with exfoliation syndrome.
    • Scanning and transmission electron microscopy of ocular tissues.

    Related Experiment Videos

  • Case study of exfoliation syndrome in an eye with an eccentric pupil.
  • Main Results:

    • Exfoliative fibrils are likely produced by the lens epithelium, iris pigment epithelium, and ciliary body epithelium.
    • Granular material on the lens capsule is deposited from the iris, particularly where it contacts the lens.
    • Material formed by the lens epithelium appears to remain within the lens capsule.

    Conclusions:

    • The term "exfoliation syndrome" is recommended over "pseudoexfoliation."
    • The iris and ciliary body epithelium are key sources of exfoliative material.
    • Understanding the origin of these deposits is crucial for managing exfoliation syndrome.