G-quadruplex DNA: a target for drug design

Carbohydrate-naphthalene diimide conjugates as potential antiparasitic drugs: Synthesis, evaluation and structure-activity studies.

European journal of medicinal chemistry·2018

Encapsulation of oligonucleotides in stealth Me.PEG-PLA50 nanoparticles by complexation with structured oligopeptides.

Drug delivery·2016

From quadruplex to helix and back: meta-stable states can move through a cycle of conformational changes.

Archives of biochemistry and biophysics·2008

[Stabilization of G x C-containing DNA duplexes by polyamides with parallel orientation in the minor groove].

Bioorganicheskaia khimiia·2004

DNA structural changes as the basis for a nanomolecular device.

Cellular and molecular biology (Noisy-le-Grand, France)·2004

Molecular recognition of quadruplex DNA by quinacridine derivatives.

Nucleosides, nucleotides & nucleic acids·2003

Immunotherapy with a short-lived anti-PD-L1 antibody in Alzheimer's disease: a phase 1b, randomized, double-blind trial.

Nature medicine·2026

Oligonucleotide-siRNA conjugate for SOD1 amyotrophic lateral sclerosis: a phase 1 trial.

Nature medicine·2026

An anti-PMEL antibody-drug conjugate with a Gq/11 inhibitor payload in GNAQ/GNA11-mutant melanomas: a phase 1 trial.

Nature medicine·2026

Anti-LAG-3 with or without anti-PD-1 in recurrent glioblastoma: a phase 1 trial.

Nature medicine·2026

Health system learning enables generalist neuroimaging models.

Nature medicine·2026

KRAS-G12D inhibitor HRS-4642 plus chemotherapy in advanced KRASG12D-mutant pancreatic cancer: a phase 1b/2 trial.

Nature medicine·2026

Generalizable structure-function covariation predictive of antidepressant response revealed by target-oriented multimodal fusion.

Nature. Mental health·2026

Integrated docking-molecular dynamics, ADME-toxicity profiling, and transcriptomic validation identify oroxylin a as a TLR7-targeting flavonoid candidate in systemic lupus erythematosus.

Frontiers in chemistry·2026

Novel seleno-ureido hybrids targeting head and neck cancer and beyond: design, synthesis, and apoptosis-mediated anticancer evaluation.

RSC advances·2026

Can Large Language Models Translate MS/MS into Molecular Caption?

Analytical chemistry·2026

Synthesis, Characterization, and Biological Evaluation of Co(II), Cu(II), and Ni(II) Complexes With 2,2'-Bipyridine-5,5'-Dicarboxamide Ligands: Antibacterial and Enzyme Inhibition Studies.

ChemistryOpen·2026

Evaluation of deep learning architectures for predicting ligand interactions with neurologically relevant GPCRs.

Journal of cheminformatics·2026

Related Experiment Videos

G-quadruplex DNA: a target for drug design

Related Concept Videos

Carbohydrate-naphthalene diimide conjugates as potential antiparasitic drugs: Synthesis, evaluation and structure-activity studies.

Encapsulation of oligonucleotides in stealth Me.PEG-PLA50 nanoparticles by complexation with structured oligopeptides.

From quadruplex to helix and back: meta-stable states can move through a cycle of conformational changes.

[Stabilization of G x C-containing DNA duplexes by polyamides with parallel orientation in the minor groove].

DNA structural changes as the basis for a nanomolecular device.

Molecular recognition of quadruplex DNA by quinacridine derivatives.

Immunotherapy with a short-lived anti-PD-L1 antibody in Alzheimer's disease: a phase 1b, randomized, double-blind trial.

Oligonucleotide-siRNA conjugate for SOD1 amyotrophic lateral sclerosis: a phase 1 trial.

An anti-PMEL antibody-drug conjugate with a G<sub>q/1</sub><sub>1</sub> inhibitor payload in GNAQ/GNA11-mutant melanomas: a phase 1 trial.

Anti-LAG-3 with or without anti-PD-1 in recurrent glioblastoma: a phase 1 trial.

Health system learning enables generalist neuroimaging models.

KRAS-G12D inhibitor HRS-4642 plus chemotherapy in advanced KRAS<sup>G12D</sup>-mutant pancreatic cancer: a phase 1b/2 trial.

Generalizable structure-function covariation predictive of antidepressant response revealed by target-oriented multimodal fusion.

Integrated docking-molecular dynamics, ADME-toxicity profiling, and transcriptomic validation identify oroxylin a as a TLR7-targeting flavonoid candidate in systemic lupus erythematosus.

Novel seleno-ureido hybrids targeting head and neck cancer and beyond: design, synthesis, and apoptosis-mediated anticancer evaluation.

Can Large Language Models Translate MS/MS into Molecular Caption?

Synthesis, Characterization, and Biological Evaluation of Co(II), Cu(II), and Ni(II) Complexes With 2,2'-Bipyridine-5,5'-Dicarboxamide Ligands: Antibacterial and Enzyme Inhibition Studies.

Evaluation of deep learning architectures for predicting ligand interactions with neurologically relevant GPCRs.

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G-quadruplex DNA: a target for drug design

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