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Long-term considerations after switching antipsychotics

P J Weiden1, R Aquila, M Emanuel

  • 1Neurobiologic Disorder Service, St. Luke's-Roosevelt Hospital Center, New York, NY 10025, USA.

The Journal of Clinical Psychiatry
|December 10, 1998
PubMed
Summary
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Atypical antipsychotics are now standard for schizophrenia treatment. This review covers managing psychopharmacologic and psychological issues during and after switching patients to these newer medications.

Area of Science:

  • Psychiatry and Pharmacology

Background:

  • Atypical antipsychotics are increasingly the standard treatment for schizophrenia.
  • Switching patients to newer antipsychotic medications necessitates careful management of potential issues.

Purpose of the Study:

  • To review common psychopharmacologic and psychological issues encountered when treating schizophrenia outpatients with atypical antipsychotics.
  • To provide guidance on managing these issues during the initial months and long-term follow-up after medication switch.

Main Methods:

  • This article presents a review of current literature and clinical considerations.
  • It synthesizes information on managing patient responses, side effects, and psychological adjustments.

Main Results:

  • Early management involves assessing response, addressing psychological reactions, and handling unsatisfactory outcomes.

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  • Longer-term considerations include combination therapy, new side effect management, and re-evaluation of treatment.
  • Psychological issues may involve changes in self-image, sexuality, intimacy, and overall recovery.

    • Conclusions:

    • Effective management of schizophrenia with atypical antipsychotics requires ongoing attention to both pharmacologic and psychological aspects.
    • Addressing these multifaceted issues is crucial for optimizing patient outcomes and recovery.
    • Clinicians should be prepared for evolving challenges throughout the treatment course.