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Related Experiment Videos

Transurethral prostate ablation using saline-liquid electrode introduced via flexible cystoscope

M F Hoey1, C M Dixon, S Paul

  • 1Department of Physiology and Urology, University of Minnesota, Minneapolis 55455, USA.

Journal of Endourology
|December 10, 1998
PubMed
Summary

This study demonstrates a new transurethral radiofrequency (RF) saline-electrode system for creating large prostate lesions. The minimally invasive technique shows promise for treating benign prostatic hyperplasia with reduced patient discomfort.

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Area of Science:

  • Urology
  • Minimally Invasive Surgery
  • Biomedical Engineering

Background:

  • Benign prostatic hyperplasia (BPH) is a common condition requiring effective treatment.
  • Current treatments for BPH can involve significant patient discomfort and side effects.
  • Radiofrequency (RF) energy delivery to prostate tissue offers a potential therapeutic approach.

Purpose of the Study:

  • To evaluate a novel transurethral flexible cystoscope-guided saline-electrode system for creating prostate lesions.
  • To assess the safety and efficacy of this minimally invasive RF energy delivery method.
  • To determine the relationship between RF energy duration and lesion volume in canine prostates.

Main Methods:

  • A 4F catheter with a 26-gauge needle electrode was introduced transurethrally via a flexible cystoscope in 10 dogs.

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  • Hypertonic saline was infused prior to and during RF energy application (50 W, 475 kHz) for varying durations (30-90 seconds).
  • Prostate and urethral temperatures were monitored, with automatic shut-off for excessive temperature or impedance.

    • Main Results:

    • Lesion volumes ranged from 0.99 cm³ to 5.03 cm³, with average volumes increasing with RF application time (1.76 cm³ at 30s to 5.03 cm³ at 90s).
    • No automatic shut-offs occurred, indicating a safe temperature and impedance profile within the tested parameters.
    • Histological examination confirmed coagulation necrosis without tissue desiccation in the treated areas.

    Conclusions:

    • Transurethral delivery of RF energy using a saline-electrode via a flexible cystoscope is a feasible and controllable method for creating large prostate lesions.
    • This minimally invasive approach demonstrates potential for effective BPH treatment with reduced patient discomfort.
    • Further research is warranted to translate these findings to human clinical applications for BPH management.