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The PIR-International Protein Sequence Database

W C Barker1, J S Garavelli, P B McGarvey

  • 1Protein Information Resource, National Biomedical Research Foundation, Washington, DC 20007, USA, USA.

Nucleic Acids Research
|December 10, 1998
PubMed
Summary
This summary is machine-generated.

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The Protein Information Resource (PIR) provides a comprehensive protein sequence database crucial for molecular evolution and genomics research. This freely accessible resource aids in sequence annotation and knowledge discovery through advanced search capabilities.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • The Protein Information Resource (PIR) has been a key resource since 1988, supporting molecular evolution, functional genomics, and computational biology.
  • It is maintained by PIR-International, an international collaboration addressing the rapid growth of sequence data and computational technologies.
  • The database is comprehensive, non-redundant, well-organized, and freely available.

Purpose of the Study:

  • To support research in molecular evolution, functional genomics, and computational biology.
  • To provide a comprehensive, non-redundant, and well-organized protein sequence database.
  • To facilitate knowledge discovery through advanced data retrieval and analysis.

Main Methods:

  • Classification of protein entries into superfamilies, families, and homology domains with available sequence alignments.

Related Experiment Videos

  • Development and maintenance of the PIR Protein Sequence Database.
  • Provision of a World Wide Web (WWW) server for on-line sequence similarity searches and information retrieval.

    • Main Results:

    • The PIR database supports comparative genomics research through full-scale family classification.
    • It aids in sequence annotation, database organization, and improves database integrity.
    • Extensive cross-referencing and hypertext-linking connect sequence entries to other major biological databases.

    Conclusions:

    • The PIR Protein Sequence Database is a vital, freely accessible resource for the scientific community.
    • Its structure and accessibility facilitate advanced research in genomics and molecular biology.
    • Regular releases and diverse access methods (WWW, FTP, CD-ROM) ensure broad usability.