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MitBASE: a comprehensive and integrated mitochondrial DNA database

M Attimonelli1, N Altamura, R Benne

  • 1Dipartimento di Biochimica e Biologia Molecolare, Università degli Studi di Bari, 70126 Bari, Italy.

Nucleic Acids Research
|December 10, 1998
PubMed
Summary

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This summary is machine-generated.

MitBASE is a comprehensive mitochondrial DNA database integrating data across species and variants. This resource supports research into mitochondrial genetic diseases and intraspecies diversity for biotechnological applications.

Area of Science:

  • Genomics
  • Bioinformatics
  • Molecular Biology

Background:

  • Mitochondrial DNA (mtDNA) data is crucial for understanding genetic diseases and intraspecies diversity.
  • Existing mtDNA data is fragmented across various sources, hindering comprehensive analysis.

Purpose of the Study:

  • To create an integrated and comprehensive database of mitochondrial DNA (mtDNA) data.
  • To provide a user-friendly platform for accessing and analyzing mtDNA information from diverse organisms and variants.

Main Methods:

  • Data aggregation from international research institutions specializing in specific organisms.
  • Database structure design and implementation by the European Bioinformatics Institute.
  • Web-based accessibility for global researchers.

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Main Results:

  • MitBASE offers a centralized repository for mitochondrial DNA information.
  • The database includes data on different organisms, intraspecies variants, and mutants.
  • A user-friendly interface facilitates data access and utilization.

Conclusions:

  • MitBASE serves as a valuable resource for basic and applied research in mitochondrial genetics.
  • The database supports advancements in understanding mitochondrial genetic diseases and intraspecies diversity.
  • This initiative, funded by the EU Biotechnology programme, enhances biotechnological research capabilities.