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HvrBase: compilation of mtDNA control region sequences from primates

F Burckhardt1, A von Haeseler, S Meyer

  • 1Max-Planck-Institut für evolutionäre Anthropologie, Inselstrasse 22-26, D-04103 Leipzig, Germany.

Nucleic Acids Research
|December 10, 1998
PubMed
Summary

HvrBase is a database of human and ape mitochondrial DNA control region sequences. It provides access to over 5,800 human and 300 ape sequences for research.

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Area of Science:

  • Genetics
  • Bioinformatics
  • Anthropology

Background:

  • Mitochondrial DNA (mtDNA) control regions are crucial for population genetics and evolutionary studies.
  • A centralized, accessible database of these sequences is needed for efficient research.

Purpose of the Study:

  • To present HvrBase, a comprehensive compilation of human and ape mtDNA control region sequences.
  • To provide researchers with easy access to sequence data and associated metadata.

Main Methods:

  • Data compilation from various sources into standardized ASCII files.
  • Development of a user-friendly Mac/PC database application with a graphical interface.
  • Web accessibility via URL: http://www.eva.mpg.de/hvrbase.

Main Results:

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  • The HvrBase collection includes 5846 human sequences from hypervariable region I (HVRI) and 2302 from hypervariable region II (HVRII).
  • Additionally, it contains 295 ape HVRI sequences and 13 HVRII sequences.
  • Data is available in both file formats and as a database application.

Conclusions:

  • HvrBase serves as a valuable resource for researchers studying human and ape mitochondrial DNA.
  • The database facilitates comparative analyses and evolutionary investigations.