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A comprehensive database for the small nucleolar RNAs from Saccharomyces cerevisiae
1Department of Biochemistry and Molecular Biology, Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, MA 01003, USA. dmitry.samarsky@ummed.edu
Nucleic Acids Research
|December 10, 1998
Summary
A new database catalogs nearly 70 small nucleolar RNAs (snoRNAs) from yeast, detailing their properties and functions in ribosome biogenesis. This resource aids researchers in exploring the roles of these crucial RNA molecules.
Area of Science:
- Molecular Biology
- Genomics
- Biochemistry
Background:
- Small nucleolar RNAs (snoRNAs) are key regulators of ribosome biogenesis in eukaryotic cells.
- Recent discoveries indicate a high diversity of snoRNAs, with up to 200 species per organism predicted.
- Understanding snoRNA function requires accessible, comprehensive data resources.
Purpose of the Study:
- To create a centralized, user-friendly database for Saccharomyces cerevisiae snoRNAs.
- To consolidate detailed information on known yeast snoRNAs and their characteristics.
- To facilitate research into snoRNA function and evolution.
Main Methods:
- Development of a web-accessible database.
- Compilation of data including genomic organization, sequences, and functional properties.
- Integration of literature references for all entries.
Main Results:
- A comprehensive database featuring nearly 70 Saccharomyces cerevisiae snoRNAs is now available.
- The database includes detailed information on snoRNA properties, homologues, and associated proteins.
- Data is organized into utilities, a master table, and individual snoRNA tables.
Conclusions:
- The yeast snoRNA database provides a valuable resource for the scientific community.
- Easy access to curated information supports diverse snoRNA research.
- This database enhances the study of ribosome biogenesis and RNA regulation.