Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

IMGT, the international ImMunoGeneTics database

M P Lefranc1, V Giudicelli, C Ginestoux

  • 1Laboratoire d'ImmunoGénétique Moléculaire, Université Montpellier II, UPR CNRS 1142 IGH, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France. lefranc@ligm.igh.cnrs.fr

Nucleic Acids Research
|December 10, 1998
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-stapled versus non-single-stapled colorectal anastomosis in minimally invasive anterior resections: a systematic review and meta-analysis.

Techniques in coloproctology·2026
Same author

Incisional hernia repair in the UK: a multicentre evaluation of guideline adherence and opportunities for service improvement.

Annals of the Royal College of Surgeons of England·2026
Same author

Black Hole Spectroscopy and Tests of General Relativity with GW250114.

Physical review letters·2026
Same author

GW250114: Testing Hawking's Area Law and the Kerr Nature of Black Holes.

Physical review letters·2025
Same author

A Novel Approach for Pollen Identification and Quantification Using Hybrid Capture-Based DNA Metabarcoding.

Ecology and evolution·2025
Same author

Review: A systematic review of dairy cow health, welfare, and behaviour in year-round loose range housing.

Animal : an international journal of animal bioscience·2025
Same journal

Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

Nucleic acids research·2026
Same journal

Correction to 'Differentiable partition function calculation for RNA'.

Nucleic acids research·2026
Same journal

Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

Nucleic acids research·2026
Same journal

Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

Nucleic acids research·2026
Same journal

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026
Same journal

Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

Nucleic acids research·2026
See all related articles

The IMGT database provides high-quality, integrated genetic information for immunoglobulins and T cell receptors in vertebrates. This resource is crucial for advancing medical research, including autoimmune diseases and antibody engineering.

Area of Science:

  • Immunoinformatics
  • Genomics
  • Molecular Biology

Background:

  • The IMGT database was established in 1989 to curate genetic information on immunoglobulins (Ig) and T cell receptors (TcR).
  • It focuses on vertebrate species, encompassing Major Histocompatibility Complex (MHC) molecules.
  • The database aims to provide a standardized and high-quality resource for immunogenetic research.

Purpose of the Study:

  • To present the IMGT database as a comprehensive, integrated resource for immunogenetics.
  • To highlight the utility of IMGT in various fields of medical and biological research.
  • To ensure free and easy data distribution for researchers worldwide.

Main Methods:

  • Creation and maintenance of specialized databases: LIGM-DB (Ig and TcR), MHC/HLA-DB, and PRIMER-DB.

Related Experiment Videos

  • Development of bioinformatics tools like IMGT/DNAPLOT for sequence analysis and alignment.
  • Expert curation of data based on the IMGT scientific chart and repertoire.

    • Main Results:

    • IMGT offers a high-quality, integrated collection of genetic data for Ig, TcR, and MHC molecules.
    • The database includes specialized sub-databases and analysis tools.
    • Expertised data and standardized nomenclature are provided.

    Conclusions:

    • IMGT is a vital resource with significant implications for medical research, including autoimmune diseases, AIDS, leukemias, and lymphomas.
    • It supports therapeutic approaches such as antibody engineering.
    • IMGT facilitates studies on genome diversity and evolution, promoting advancements in immunology and related fields.